Section on Eukaryotic Transposable Elements
Publications

Cam, H., Noma, K., Ebina, H., Levin, H., and Grewal, S., (2008), Host genome surveillance for retrotransposons by transposon-derived proteins, Nature 451:431-436.

Gao, X., Hou, Y., Ebina, H., Levin, H. and Voytas, D. (2008), Chromodomains direct integration of retrotransposons to heterochromatin, Genome Research 18:359-369.

Ebina, H., Chatterjee, A. Judson, R., and Levin, H. (2008) The GP(Y/F) domain of Tf1 integrase multimerizes when present in a fragment, and substitutions in this domain reduce enzymatic activity of the full-length protein., Journal of Biological Chemistry 283:15965-74.

Leem,Y., Kelly, F., Ripmaster, T., Heincelman, M., Hoffman, C., and Levin, H. (2008) Retrotransposons of S. pombe target and repair pol II promoters, Mol. Cell 30:98-107.

Evertts, A., Plymire, C., Craig, N., and Levin, H. (2007) The hermes transposon of Musca domestica has robust activity in Schizosaccharomyces pombe that disrupts open reading frames, Genetics 177:2519-2523.

Ebina, H. and Levin, H. (2007) Stress Management:  How cells take control of their transposons, Mol. Cell, 27: 180-181.

Levin, H. (2007) Metaviruses, in Encyclopedia of Virology, Eds Mahy and Van Regenmortel, Elsevier Limited Oxford, UK.

Atwood-Moore A, Yan, K, Judson, R., Levin H. (2006) The self primer of the long terminal repeat retrotransposon Tf1 is not removed during reverse transcription, Journal of Virology, 80: 8267–8270.

Atwood-Moore A, Ejebe K, Levin H. (2005) Specific Recognition and Cleavage of the Plus-Strand Primer by Reverse Transcriptase, Journal of Virology, 79:14863-14875.

Hizi, A., and Levin, H. (2005) The integrase of the LTR-retrotransposon Tf1 has a chromodomain that modulates integrase activities, Journal of Biological Chemistry, 280: 39086-39094.

Kim, M., Claiborn, K., and Levin, H. (2005) The long terminal repeat-containing retrotransposon Tf1 possesses amino acids in Gag that regulate nuclear localization and particle formation. Journal of Virology, 79:9540-9555.

Kelly, F., and Levin, H. L. (2005) The evolution of retrotransposons in Schizosaccharomyces pombe, Cytogenetics and genome Research, 110:566-574.

Levin, H. (2003), The Retrotransposons of Schizosaccharomyces pombe. The Molecular Biology of Schizosaccharomyces pombe. Springer, Heidelberg.

Silverstein, R., Richardson, B., Levin, H., Allshire, R., and Ekwall, K. (2003) A new role for the transcriptional co-repressor SIN3; regulation of centromeres. Current Biology, 13:68-72.

Teysset, L., Dang, V., Kim, M., and Levin, H. (2003) An LTR-retrotransposon of Schizosaccharomyces pombe expresses a Gag-like protein that assembles into virus-like particles and mediates reverse transcription. Journal of Virology, 77:5451-5463.

Levin, H. (2002) Newly identified retrotransposons of the gypsy/Ty3 class in fungi, plants, and vertabrates. Mobile DNA II. American Society of Microbiology, Washington, DC.

Singleton, T., and Levin, H. (2002). An LTR-retrotransposon of fission yeast has strong preferences for specific sites of insertion. Eukaryotic Cell, 1:44-55.

Dang, V., and Levin, H. (2000). Nuclear import of the retrotransposon Tf1 is governed by a nucler localization signal that possesses a unique requirement for the FXFG nucler pore factor Nup124p. Mol. and Cell. Biol. 20:7798-7812.

Haag, L. E., Lin, J., and Levin, H. L. (2000) Evidence for the packaging of multiple copies of Tf1 mRNA into particles and the trans priming of reverse transcription. Journal of Virology 74:7164-7170.

Balasundaram, D., Benedik, M., Dang, V., Morphew, M. and Levin H. (1999) Nup124p is a nuclear pore factor of Schizosaccharomyces pombe that possesses a specialized function required for the nuclear import of the retrotransposon Tf1. Mol. and Cell. Biol. 19:5768-5784.

Dang, V., Benedik, M., Ekwall, K., Choi, J., Allshire, R., and Levin, H. (1999) Silencing factor sin3 is essential for cell viability and required for retroelement propagation in fission yeast. Mol. and Cell. Biol. 19:2351-2365.

Atwood, A., Choi, J., and Levin, H. (1998) A genetic assay for homologous recombination of reverse transcripts enabled the identification of amino acids encoded by an LTR-retrotransposon that were critical for integration. Journal of Virology 72:1324-1333.

Hoff, E., Levin, H., and Boeke, J. (1998) The Schizosaccharomyces pombe retrotransposon Tf2 mobilizes primarily through homologous cDNA recombination. Mol. and Cell. Biol. 18:6839-6852.

Lin, J., and Levin, H. L. (1998) Reverse transcription of a self-primed retrotransposon requires an RNA structure similar to the U5-IR stem-loop of retroviruses. Mol. and Cell. Biol. 18:6859-6869.

Steele, S. J., Levin, H. L. (1998) A map of interactions between the proteins of a retrotransposon. Journal of Virology 72:9318-9322.

Levin, H. L. (1997) It's prime time for reverse transcriptase. Cell 88:5-8.

Lin, J., and Levin, H. (1997) A complex structure in the mRNA of Tf1 is recognized and cleaved to generate the primer of reverse transcription, Genes and Development 11:270-285.

Lin, J., and Levin, H. (1997) Self-primed reverse transcription is a mechanism shared by several LTR-containing retrotransposons. RNA 3:952-953.

Atwood, A., Lin, J., and Levin, H. (1996) The retrotransposon Tf1 assembles virus-like particles that contain excess Gag relative to integrase due to a regulated degradation process. Mol. and Cell. Biol. 16:338-346.

Levin, H. L. (1996) An unusual mechanism of self-primed reverse transcription requires RNase H for cleavage of an RNA duplex. Mol. and Cell. Biol. 16:5645-5654.

Levin, H. L. (1995). A novel mechanism of self-primed reverse transcription defines a new family of retroelements. Mol. and Cell. Biol. 15: 3310-3317.

Levin, H. L., Weaver, D. C., and Boeke, J. D. (1993). Novel gene expression mechanism in a fission yeast retroelement: Tf1 proteins are derived from a single primary translation product. EMBO J.12:4885-4895.

Weaver, D., Shapakovski, G., Caputo, E., Levin, H., and Boeke, J. (1993) Sequence analysis of closely related retrotransposon families from fission yeast. Gene, 131:135-139.

Levin, H.L. and Boeke, J.D. (1992). Demonstration of retrotransposition of the Tf1 element in fission yeast. EMBO J. 11:1145-1153.

Levin, H. L. and Boeke, J. D. (1990). The Absence of adenine methylation increases the ligation efficiency of partially filled staggered DNA ends. Nucl Acids Res. 18:6146.

Levin, H. L., Weaver, D. C., and Boeke, J. D. (1990). Two related families of retrotransposons from Schizosaccharomyces pombe. Mol. and Cell. Biol. 10:6791-6798.

Sikorski, R. S., Michaud, W., Levin, H. L., Boeke, J. D. and Hieter, P. (1990). Trans-kingdom promiscuity with S. pombe. Nature 345: 581-582.

Section on Eukaryotic Transposable Elements DIR Eunice Kennedy Shriver National Institute of Child Health and Human Development NIH DHHS USA.gov Laboratory of Gene Regulation and Development Web site